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Controversies to Consensus in Diabetes, Obesity
and Hypertension (CODHy)
October 30 - November 2, 2008, Barcelona, Spain
 
  Diabetes

 
1. What Should be the Treatment of a Person with IGT/ Newly Diagnosed Diabetes who Fails Lifestyle Modifications?
Metformin
TZDs
Insulin
GLP1/DPP4 
Combination therapy
 
2. Changing the Treatment Paradigm of T2DM – Evidence from Ongoing Studies: 
  Early combination therapy
GLP-1/ DPP-IV inhibitors/pramlintide
Anti-inflammatory agents
"Diabetic Bariatric surgery"
 
3.  Use of Insulin in T2DM
Safety of inhaled insulin in T2DM
Comparison of different insulin regimens in T2DM based on evidence based medicine
Substitution of first phase insulin response in T2DM patient
When and how to intensify insulin treatment in T2DM
 
4.  What is the Best Means to Treat Fasting Hyperglycemia in T2DM? 
Night-time long acting insulin/Premixed insulin
Oral agents that block gluconeogenesis
Novel agents – CB-1 antagonists, GLP 1 and DPP4 inhibitors, GK activators
 
5.
Glitazone / PPAR alpha/gama in Type 2 Diabetes
Pros
Cons
 
6. Future Treatment / Cure of T1DM – What will bring the breakthrough?
Stem cell therapy
Islet cell transplantation
Closed-loop insulin delivery system (artificial pancreas)
Salvage of existing beta cells
 
7. Therapy for LADA and for Protection of Beta Cell Function in T1DM diagnosed in Adult age
The natural history of beta cell function in LADA and in Type 1 diabetes diagnosed in adult age
LADA: sulphonylureas vs. metformin, vs. glitazones. vs. insulin: pros and cons for protection of beta cell function
Antigen specific therapy (GAD and Diapep277)
Immunomodulatory treatment (anti-CD3 and other agents)
 
8. Multiple Events of Mild Hypoglycemia – A Price Worth Paying for Improved Glucose Control? 
Pros
Cons
 
9. Blood Glucose Self-Monitoring in Non Insulin Treated Patients is:
Good value and appropriately used in diabetes management
Too costly and inappropriately used in diabetes management
 
10.  Continuous Glucose Monitoring (CGM) - Who will benefit from it?
T1DM
T2DM
ICU setting
The place for advisory/auxiliary tools to improve diabetes control
11. Intensive Glycemic Control in Hospitalized Patients/ICU – Is it mandatory and How?
Yes
No
 
12.
 Role of Mitochondria in Aging and Diabetes 
The muscle
The beta cell
   
 13.  Novel Markers of Diabetes Control - What should be the Gold Standard?
  HbA1c is still the best
Glucose variability as a target for intervention
Mean glucose and deviations
 

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